This is probably the only post that will tell the the correct way to set these two knobs together. Please leave comments.
First, start off by leaving your car turned-off (if the radio is mobile). Second, turn both the Squelch and the RF Gain all the way down (counter-clockwise). Third, turn the main volume almost all the way up. Forth, begin raising the Squelch very slowly and stop right when the radio gets silent. Finally, slowly raise the RF Gain until you hear static and noise, then turn it back down slowly just until the static and noise stops; this will let you hear only voices and not annoying static.
By keeping the controls down as low as possible, it will help you hear every signal, and it will eliminate static and unintelligible signals. I hope this post helped you all out. I am going to turn this blog into a CB Radio Page so please bookmark this. Have a great time and enjoy your CB radio.